Principal Investigator  or Search All Ladiges, Warren Stambrook, Peter Wiley, Jesse Preston, Brad van der horst, Bert Hoeijmakers, Jan Jacks, Tyler Kucherlapati, Raju Edelmann, Winfried Vijg, Jan van Steeg, Harry Kemp, Chris Doetschman, Thomas Gu, Yansong DiGiovanni, John Johnson, David Mouse Model Name  or Search All RPA (variant in DNA binding domain) Plap-Fs pUR 288-lacZ 30 Plap-ti MIh1 (S44F) ATPase Aprt null Cyclin Db1 (A870G/exon 5) P53(S389A) Xpd SNP creK5 pUR 288-lacZ 60 p53BAC R72 CycD1bK5(A870G/exon5) Gal4 E2F1 MCAT Tg XRCC1 (R194W) ki Msh6(T1217D) Fen1 null Brca1 cre Null P53(R270H) P53.R270H/Wap-Cre P53.R270H/balancer-Cre P53.R270H/K14Cre Xpa cond P53 (P72) P53 (R72 / R270H) P53 (P72 / R270H) p53 BAC P72 ATF3.BK5 Ercc1 cond Plk1 null Tdp-1 ko POLdelta1 (D400A) Tdg ko XRCC1 cko Parp1 null DNAjC3(tm-gfp) TCR alpha/beta Tg P27 (R15W) ATF3 (T38M) MIh1 null Msh2 null Msh2 (G674A) ATPase Msh2 (G674D) ATPase Exo 1 null PCNA Pol130-104 MBD4 null XPV null Chk1 (L449R) non catalytic Chk1 (R155Q) catalytic Rb (R654W) Cyclin D1b tg Chk2 (I157D) P53 (R72) BRCA2 K322N ATM null XRCC1 (R280H) ki Aptx cko (conditional knock out) Xrcc1 (V86R) ki XRCC1 (L360R) Ki Ku70 null PRKR WRN (R834C) Ki WRN (E84A) ki Plk3 Null WRN k577m ki Chk2 1100delC P27 V109G WRN K577M Tg BRCA2 K322Q Polymerase ε r1382c ki Polymerase γ r1146c ki RecQL4 POLdelta1 (L604G) catalytic POLdelta1 (L604K) catalytic Gene Name or Search All None Selected adenomatosis polyposis coli APEX nuclease (multifunctional DNA repair enzyme) 1 ataxia telangiectasia mutated (includes complementation groups A, C and D) breast cancer 1, early onset cyclin D1 (PRAD1: parathyroid adenomatosis 1) cyclin H cyclin-dependent kinase inhibitor 1A (p21, Cip1) cyclin-dependent kinase inhibitor 1B (p27, Kip1) CHK1 checkpoint homolog (S. pombe) CHK2 checkpoint homolog (S. pombe) cytokine-inducible kinase E2F transcription factor 1 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D) flap structure-specific endonuclease 1 ligase IV, DNA, ATP-dependent O-6-methylguanine-DNA methyltransferase mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) mutS homolog 3 (E. coli) mutS homolog 4 (E. coli) mutS homolog 5 (E. coli) mutS homolog 6 (E. coli) 8-oxoguanine DNA glycosylase proliferating cell nuclear antigen polo-like kinase 1 (Drosophila) PMS2 postmeiotic segregation increased 2 (S. cerevisiae) polymerase (DNA directed), beta polymerase (DNA directed), delta 1, catalytic subunit polymerase (DNA directed), epsilon polymerase (DNA directed), gamma polymerase (DNA directed), eta polymerase (DNA directed) kappa polymerase (DNA directed), mu protein kinase, interferon-inducible double stranded RNA dependent retinoblastoma 1 (including osteosarcoma) tumor protein p53 (Li-Fraumeni syndrome) POLs... Werner syndrome X-ray repair complementing defective repair in Chinese hamster cells 1 xeroderma pigmentosum, complementation group A exonuclease 1 adenine phosphoribosyl transferase activating transcription factor 3 methyl-CpG binding domain protein 4 DnaJ (Hsp40) homolog, subfamily C, member 3 proviral integration site 1 replication protein A1 polo-like kinase 3 (Drosophila) Thyroid autoantigen 70kDa, Ku antigen Mitochondrial - Targeted Catalase amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) Gene Symbol or Search All None Selected APC APEX1 ATM BRCA1 CCND1/Cyclin D1 CCNH/cyclin H CDKN1A/p21 CDKN1B/p27 CHEK1/CHK1 CHEK2/CHK2 CNK/PLK3 E2F1 ERCC1 ERCC2 FEN1 LIG4 MGMT MLH1 MSH2 MSH3 MSH4 MSH5 MSH6 OGG1 PCNA PLK1 PMS2 POLB POLD1 POLE POLG POLH POLK POLM PRKR RB1 TP53 WRN XRCC1 XPA EXO1 APRT ATF3 MBD4 DNAJC3 PIM1 RPA1 PLK3 G22P1 MCAT APP Status or Search All None Selected available created, under evaluation under generation planned Genetic Manipulation Type   Search All transgenic targeted other None selected Gene Trap Genetic Mutation Type   Search All Null Insertion Deletion Point Mutant loxP Sites None selected SNP Mouse Line   Search All 129P1/ReJ 129P3/J 129P3/JEms 129P4/RrRk 129S1/SvImJ 129T2/SvEms 129T2/SvEmsJ 129X1/SvJ A/HeJ A/J A/WySnJ AKR/Cum AKR/J ALR/LtJ ALS/LtJ AU/SsJ BALB/cAnLil BALB/cBiDsm BALB/cByJ BALB/cGa BALB/cGrRk BALB/cJ BALB/cWtEi BDP/J BPH/2@J BPL/1@J BPN/3@J BRVR/WrDv BTBR + tf/tf (black and tan/brachyury) BUB/BnJ C3H/HeJ C3H/HeJSx C3H/HeOuJ C3H/HeSnJ C3HeB/FeJ C3HfB/Bi C57BL/6ByJ C57BL/6J (Black 6) C57BL/6JEi C57BL/10J C57BL/10ScSn C57BL/10SnJ C57BL/10Sx C57BL/10WtRk C57BLKS/J C57BR/cdJ C57L/J C58/J CBA/CaGnLe CBA/CaH-T6/J CBA/CaHN-Btk(xid)/J CBA/CaJ CBA/J CE/J DA/HuSn DBA/1J (D1) DBA/1LacJ DBA/2Bi DBA/2DeJ DBA/2HaSmn DBA/2J DBA/8BiDsm DDY/Jc1 EL/Sa1 EL/Suz FL/1Re FL/4Re FLB/NJ HTG/GoSfSn I/LnJ B6 x IDH2/Ei KK/H1J LDH2/Ei LG/J LP/J LT/SvEi MA/MyJ MRL/MpJ NH/KiPt NOD/LtJ NON/LTJ NOR/LtJ NZB/B1NJ NZM88/J NZM88/J NZM391/J NZM2328/J NZM2410/J NZO/H1J NZO/H1Lt NZW/LacJ P/J PL/J PRO/Re RBF/DnJ RF/J RIII/DmMob RIIIS/J SB/Le SEA/GnJ SEC/1ReJ SENCARB/PtJ SENCARC/PtJ SI SIM/Ut SJL/Bm SJL/J SM/J SOD1/Ei ST/bJ SWR/Bm SWR/J YBR/Ei None selected FVB Projected Use or Search All AGING, CANCER, CARDIOVASCULAR DISEASE APOPTOSIS AND CELL CYCE REGULATION ASSOCIATED WITH INTERFERON SENSTIVITY CANCER CANCER, AGING, MUTATOR PHENOTYPE CREATES A NEW KNOCKOUT IN WHICH EXONS 3 THROUGH 17 OF GENE ARE REMOVED. INSERTION OF A NEO CASSETTE FLANKED BY LOXP AND 2272 LOXP DERIVATIVE SITES ALLOW REPLACEMENT WITH MODIFIED VERSIONS OF THE XRCC1 GENE. DELETION ASSESSMENT FREE RADICAL THEORY OF AGING, ARTERIOSCLEROSIS, NEOPLASIA, CATARACTS, LONGEVITY GENE INTERACTION STUDIES WITH XRCC1, P58IPK, AND WRN MAMMARY CANCER MOTOR COORDINATION DEFICITS, IMMUNE DEFICIENCIES, CANCER, ATAXIA, GENOTOXIC STRESS, AGING MUTATION FREQUENCY DETERMINATION MUTATION FREQUENCY DTERMINATION POINT MUTATION AFFECTING XRCC1 FUNCTION AND TOXICOLOGICAL SENSTIVITY PROTOTYPE TO STUDY DECREASED EXPRESION OF XRCC1 PROTEIN IN SINGLE STRAND BREAK REPAIR. SNP ASSESSMENT SNP ASSESSMENT, BLADDER CANCER SNP ASSESSMENT, BREAST CANCER SNP ASSESSMENT, CANCER SNP ASSESSMENT, CANCER, AGING SNP ASSESSMENT, CANCER AND AGING SNP ASSESSMENT, GI CANCER SNP ASSESSMENT, SKIN CANCER SNP ASSESSMENT, UV SKIN CANCER SNP INVESTIGATION TOOL, BREAST CANCER TOOL, CANCER TOOL, DIABETES TOOL, FRAME SHIFT INDICATOR MOUSE TOOL, GI CANCER TOOL, LOH INDICATOR MOUSE. TOOL, TRANSITION INDICATOR MOUSE UV SKIN CANCER, AGE-RELATED CARCINOGENESIS, AGEING UV SKIN CANCER, AGE-RELATED CARCINOGENESIS, AGING VARIANT ASSESSMENT Disease or Search All CANCER DIABETES WERNER'S SYNDROME, CANCER WERNER SYNDROME; AGING Gene Ontology Terms function Search All ADENINE PHOSPHORIBOSYLTRANSFERASE ACTIVITY ATP-DEPENDENT HELICASE ACTIVITY CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR ACTIVITY CYCLIN-DEPENDENT PROTEIN KINASE REGULATOR ACTIVITY DNA BINDING DNA EXCISION DNA REPAIR ENDONUCLEASE ACTIVITY EXONUCLEASE EXONUCLEASE ACTIVITY HELICASE ACTIVITY HYDROLASE ACTIVITY KINASE ACTIVITY NUCLEIC ACID BINDING NU DNA POLYMERASE ACTIVITY PROTEIN BINDING PROTEIN KINASE ACTIVITY PROTEIN KINASE INHIBITOR ACTIVITY REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY TRANSCRIPTIONAL REPRESSOR ACTIVITY TRANSCRIPTION FACTOR ACTIVITY TRANSFERASE ACTIVITY TRANSFERASE ACTIVITY, TRANSFERRING GLYCOSYL GROUPS TRANSFORMING GROWTH FACTOR BETA RECEPTOR, CYTOPLASMIC MEDIATOR ACTIVITY process Search All ADENOSINE SALVAGE CELL CYCLE CELL CYCLE ARREST CELL CYCLE CHECKPOINT CELL GROWTH AND/OR MAINTENANCE DEFENSE RESPONSE DNA METHYLATION DNA MISMATCH REPAIR DNA REPAIR DNA REPLICATION GLUCONEOGENESIS NEGATIVE REGULATION OF CELL PROLIFERATION NUCLEOTIDE-EXCISION REPAIR PURINE RIBONUCLEOSIDE SALVAGE REGULATION OF TRANSCRIPTION, DNA-DEPENDENT RESPONSE TO DNA DAMAGE STIMULUS TELOMERE MAINTENANCE component Search All CYTOPLASM NUCLEUS TRANSCRIPTION FACTOR COMPLEX

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